1.
Bioorg Chem
; 146: 107257, 2024 May.
Article
En
| MEDLINE
| ID: mdl-38493639
Quorum-sensing (QS) is a cell density-dependent signaling pathway regulated by gene expression for intra- and interspecies communication. We have targeted QS activity in Pseudomonas aeruginosa, an opportunistic human pathogen that causes disease in immunocompromised patients, with a set of probes containing a variety of functional groups, including photoreactive (diazirine) and affinity (alkyne) moieties, that were synthesized using a four-component Ugi reaction (Ugi-4CR).
Pseudomonas Infections , Pseudomonas aeruginosa , Humans , Bacterial Proteins/metabolism , Pseudomonas Infections/drug therapy , Quorum Sensing , Diazomethane/chemical synthesis , Diazomethane/chemistry